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KMID : 0367419740150050048
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Journal of Korean Pediatric Society
1974 Volume.15 No. 5 p.48 ~ p.51
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Comparison of Efficacy of Various Oral-Hypoglycemic Agents on Diabetes Insipidus
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김홍규/Kim, Hong Kyu
박양현/염은열/김기복/Park, Yang Hyun/Yum, En Yul/Kim, Ki Bok
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Abstract
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The efficacy of three oral hypoglycemic agents, all sulfonylurea derivatives (chlorpropamide, Tollbutamide and Tolazamide) were compared in the case of a 6-year-old girl suffering from diabetes insipidus. chlorpropamide was demonstrated to be the most effective, Tolbutamide slightly effective, and Tolbutamide lacked antidiuretic action.
Comparison of molecular structures of these agents revealed that replacement of Cl in para-position with methyl radical did not greatly influence the antidiabetic efficacy, whereas replacing the propyl radical with other complex radicals markedly affects the efficacy.
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